A Piranha Plant, known as Packun Flower (パックン フラワー Pakkun Furawā?) in Japan,[30] is an enemy almost always portrayed as a leafy, green stalk topped with a white-spotted red or green globe and sharp teeth. Piranha Plants usually come up from pipes, but sometimes they may also simply stick up from the ground. In Super Mario Galaxy, two stronger versions of a Piranha plant, Dino Piranha and Flaming Dino Piranha, appear. Another Piranha Plant Boss, Peewee Piranha, appears in Super Mario Galaxy 2. Some Piranha Plants spit fireballs and are known as Venus Firetraps, also referred to as Petite Piranhas. Another kind, introduced in the handheld game Super Mario 3D Land, are Inky Piranha Plants, which spit out ink that covers almost the whole screen.

Piranha Plants appear in the television series. They have made cameos in Tetris Attack and The Legend of Zelda: Link's Awakening.[31] They also appear in Super Smash Bros. in the Mushroom Kingdom stage, and later in Super Smash Bros. Brawl in the PictoChat stage, and as a collectible trophy.

GameDaily listed Piranha Plant as the 13th best Mario enemy.[32] listed Piranha Plant first in their list of the "Top 5 Enemy Plants".[33]